Chlorpromazine, colza pine, and lox pine are the majority likely agents to create seizures. Most other narcoleptics, though, are unusually connected with seizures, even after overdose. The instrument by which narcoleptics create seizures is not well understood but probable involves dose-related blockade of nor epinephrine reuptake and antagonism of gamma-amino butyric acid a receptors. Narcoleptic agents have a comparatively flat dose-response bend. Effectual therapeutic doses vary over a wide variety. The most favorable dose is determined by the scientific retort, not by serum drug levels. Pharmacologic belongings usually last 24 hours or more, allowing for once-daily dosing.